Recombinant Mouse FGCP/GCPII/mGCP/NAALADase I/PSMA (N-6His)

Specifications

Catalog number

PKSM041421-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Glutamate carboxypeptidase 2, also known as FOLH1, PSMA, belongs to the M28B subfamily and the peptidase M28 family. It is highly expressed in prostate epithelium and can be detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level) . PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease. It has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. PSMA involves in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, PSMA cleaves Gly-Pro-AMC. PSMA is stable at pH greater than 6.5.

Abbreviation

FGCP; GCPII; mGCP; PSMA

Synonyms

Cell growth-inhibiting gene 27 protein; FGCP; Folate hydrolase 1; GCPII; Glutamate carboxypeptidase 2; NAALADase I; PSMA; mGCP

UniProt

Q0VDM5

Accession Number

Q0VDM5

Expression System

HEK293 Cells

Tag

N-His

Sequence

Ile44-Ala752

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

80.7 kDa

Observed Molecular Weight

100-120 kDa

Species

Mouse