Recombinant Mouse IL-11RA (C-6His)

Specifications

Catalog number

PKSM041427-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin 11 receptor alpha (IL 11 R alpha, IL 11 R alpha 1) originally designated NR1 in mouse, is a 49 kDa type I transmembrane protein that is a member of the gp130 subfamily of the hematopoietic cytokine receptor family. IL-11 R alpha first binds IL 11 with low affinity, then forms a high affinity receptor when complexed with gp130 homodimers. IL 11 R alpha is also anti-apoptotic for colonic epithelia, and increased IL 11 signaling may be a factor in inflammation-associated gastrointestinal cancer development. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.A soluble form (sIL11RA) can act as an antagonist of IL11-dependent cell differentiation in cells where both transmembrane IL11RA and IL6ST are present.

Abbreviation

IL-11RA

Synonyms

Etl; IL-11 R alpha; IL11R alpha; IL-11Ra; Il11ra2; NR1; Etl2; Il11ra; Il11ra1; AI314697; GP130; RP23-167I12.2

UniProt

Q64385

Accession Number

Q64385

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser24-Gln367

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38.5 kDa

Observed Molecular Weight

40-55 kDa

Species

Mouse