Recombinant Mouse IL-6 Receptor Subunit alpha/IL-6RA/CD126 (C-6His)

Specifications

Catalog number

PKSM041429-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

Abbreviation

IL-6RA; CD126

Synonyms

MGC; Membrane glycoprotein; IL-6R-Alpha; IL6RQ; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC30256; CD126; gp80; IL6Q; IL-6R; IL-6R 1; IL-6R subunit alpha; IL-6R-1; Il6r; Il6ra; IL-6Rα IL-6RA; interleukin 6 receptor; Interleukin-6 receptor

UniProt

P22272

Accession Number

P22272

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu20-Pro364

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38.9 kDa

Observed Molecular Weight

50-65 kDa

Species

Mouse