Recombinant Mouse Pentraxin-related protein PTX3 (N-6His)

Specifications

Catalog number

PKSM041439-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.

Abbreviation

Pentraxin-relatedPTX3

Synonyms

PTX3; Pentaxin-related protein PTX3; Pentraxin 3; alpha-induced protein 5; long; pentaxin-related gene; pentraxin 3; pentraxin-3; pentraxin-related gene; pentraxin-related protein PTX3; rapidly induced by IL-1 beta; tumor necrosis factor

UniProt

P48759

Accession Number

P48759

Expression System

HEK293 Cells

Tag

N-His

Sequence

His18-Ser381

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

41.0 kDa

Observed Molecular Weight

54 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

Species

Mouse