Recombinant Mouse TrkC/Ntrk3 (C-6His)

Specifications

Catalog number

PKSM041444-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT-3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC only binds NT-3. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system. Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

Abbreviation

TrkC; Ntrk3

Synonyms

GP145-TrkC; NT-3 Growth Factor Receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC; TrkC tyrosine kinase; trk-C

UniProt

Q6VNS1

Accession Number

Q6VNS1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Cys32-Thr429

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

45.5 kDa

Observed Molecular Weight

80-110 kDa

Species

Mouse