Recombinant Mouse Siglec-E (C-Fc) — image 1 of 3

Product details

Recombinant Mouse Siglec-E (C-Fc)

Q: What is the catalog number for Recombinant Mouse Siglec-E (C-Fc)?

The catalog number for Recombinant Mouse Siglec-E (C-Fc) is PKSM041446.

Q: What sizes are available for Recombinant Mouse Siglec-E (C-Fc)?

Recombinant Mouse Siglec-E (C-Fc) is available in the following size(s): 10 µg, 50 µg.

Q: How many pack sizes does Recombinant Mouse Siglec-E (C-Fc) come in?

Recombinant Mouse Siglec-E (C-Fc) is available in 2 different pack sizes.

Q: Is Recombinant Mouse Siglec-E (C-Fc) in stock?

Recombinant Mouse Siglec-E (C-Fc) is currently made to order / not held in immediate stock. Contact us for lead time.

Q: Who manufactures Recombinant Mouse Siglec-E (C-Fc)?

Recombinant Mouse Siglec-E (C-Fc) is manufactured by Elabscience.

Q: What is the estimated delivery time for Recombinant Mouse Siglec-E (C-Fc)?

Estimated delivery time for Recombinant Mouse Siglec-E (C-Fc) is approximately 15 business day(s), depending on your location.

Q: Where can I find the safety data sheet (SDS/MSDS) for Recombinant Mouse Siglec-E (C-Fc)?

The safety data sheet for Recombinant Mouse Siglec-E (C-Fc) is available here: https://789.bio/eb/yP0uvT.

Q: What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

Q: What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

Q: How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Catalog number PKSM041446-01

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Price for PKSM041446-01

Size / count 10 µg

Specifications

Catalog number: PKSM041446-01
Size / count: 10 µg
Dry ice: No
Hazardous: No
Discontinued: No
Background: Siglecs are sialic acid specific I-type lectins that are characterized by an extracellular domain (ECD) with an N-terminal Ig-like V-set domain followed by varying numbers of Ig-like C2-set domains. Mouse Siglec-E, also known as Myeloid Inhibitory Siglec (MIS), is an 80 - 85 kDa member of the CD33-related subfamily of Siglecs. Rodent and primate Siglec gene families have significantly diverged, and Siglec-9 is the most likely human ortholog of mouse Siglec-E. Siglec-E is expressed as a heavily N-glycosylated disulfide-linked homodimer and shows binding preference for disialic acids in the alpha 2-8 linkage. Siglec-E is up-regulated and additionally phosphorylated following cellular stimulation by a variety of TLR agonists. Siglec-E signaling negatively regulates the LPS-induced production of TNF- alpha and IL-6 by macrophages. Its up-regulation in macrophages parallels the development of endotoxin tolerance. Siglec-E recognition of sialylated determinants on virulent T. cruzi contributes to the suppression of dendritic cell IL-12 p40 production.
Abbreviation: Siglec-E
Synonyms: Sialic Acid Binding Ig-like Lectin E; Siglec-E; SiglecE
UniProt: Q6PJ50
Accession Number: Q6PJ50
Expression System: HEK293 Cells
Tag: C-Fc
Sequence: Gln20-Phe355
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Purity: > 95 % as determined by reducing SDS-PAGE.
Bioactivity: Not validated for activity
Reconstitution: Please refer to the printed manual for detailed information.
Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight: 64.4 kDa
Observed Molecular Weight: 85-95 kDa
Species: Mouse

Frequently Asked Questions

What is the catalog number for Recombinant Mouse Siglec-E (C-Fc)?

The catalog number for Recombinant Mouse Siglec-E (C-Fc) is PKSM041446.

What sizes are available for Recombinant Mouse Siglec-E (C-Fc)?

Recombinant Mouse Siglec-E (C-Fc) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Mouse Siglec-E (C-Fc) come in?

Recombinant Mouse Siglec-E (C-Fc) is available in 2 different pack sizes.

Is Recombinant Mouse Siglec-E (C-Fc) in stock?

Recombinant Mouse Siglec-E (C-Fc) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Mouse Siglec-E (C-Fc)?

Recombinant Mouse Siglec-E (C-Fc) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Mouse Siglec-E (C-Fc)?

Estimated delivery time for Recombinant Mouse Siglec-E (C-Fc) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Mouse Siglec-E (C-Fc)?

The safety data sheet for Recombinant Mouse Siglec-E (C-Fc) is available here: https://789.bio/eb/yP0uvT.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.