Recombinant Mouse IL-36RA protein (His Tag)

Specifications

Catalog number

PKSM041482-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family) . IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9) . Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.

Abbreviation

IL-36RA

Synonyms

EBI; Interleukin; Il1f; Il1h; Il1hy; EBI3; EBV-induced gene 3 protein; Epstein-Barr virus-in duced gene 3 protein; IL-27-A; IL-27B; IL-30; Interleukin-27 subunit alpha; Interleukin-27 subunit beta; Interleukin-30; p28; Fil1d; Il1f5; Il1h3; Il1hy1; IL36RN

UniProt

Q9QYY1

Accession Number

Q9QYY1

Expression System

E.coli

Tag

C-His

Sequence

Met 2-Asp 156

Applications

Cell culture

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

17.8 kDa

Observed Molecular Weight

17-25 kDa

Species

Mouse