Recombinant Mouse CCL2 protein (His Tag)

Specifications

Catalog number

PKSM041504-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP) -1 and small inducible cytokine A2 (SCYA2) ), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Recently research also showed that CCL2 might be useful as a biomarker of fibrosis as well as a target for therapeutic intervention.

Abbreviation

CCL2

Synonyms

1110006O16Rik;1700006N07Rik; Zcyto; Zcyto7

UniProt

P10148

Accession Number

P10148

Expression System

E.coli

Tag

N-His

Sequence

Gln 24-Asn 148

Applications

Cell culture

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.7 kDa

Observed Molecular Weight

17-25 kDa

Species

Mouse