Recombinant Cynomolgus LAG-3/CD223 Protein (Fc Tag)

Specifications

Catalog number

PKSQ050015-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human Lymphocyte activation gene 3 protein (LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.

Abbreviation

LAG-3; CD223

Synonyms

CD223; LAG-3; LAG3; Lymphocyte activation gene 3 protein; Protein FDC

Accession Number

XP_005570011.1

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ala18-His449 (Pro74)

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

73.6 kDa

Observed Molecular Weight

90 kDa

Species

Cynomolgus macaques