Recombinant Cynomolgus CD3d/CD3 delta Protein (Fc Tag)

Specifications

Catalog number

PKSQ050020-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

T-cell surface glycoprotein CD3 delta chain (CD3D) is a single-pass type I membrane protein. CD3D, together with CD3-gamma, CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. CD3 chains are present as CD3gammaepsilon, deltaepsilon, and zetazeta dimers in the receptor complex and play critical roles in the antigen receptor assembly, transport to the cell surface, and the receptor-mediated signal transduction. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) . CD3D contains 1 ITAM domain and has been shown to interact with CD8A.

Abbreviation

CD3d; CD3 delta

Synonyms

CD3D; CD3d; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain

UniProt

Q95LI8

Accession Number

Q95LI8

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Phe22-Ala105

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

36.7 kDa

Observed Molecular Weight

50-65 kDa

Species

Cynomolgus macaques