Recombinant Cynomolgus OX40 Ligand/TNFSF4/OX40L Protein (His Tag)

Specifications

Catalog number

PKSQ050028-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor necrosis factor ligand superfamily member 4 (TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. It is a cytokine that binds to TNFRSF4, Co-stimulates T-cell proliferation and cytokine production. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells.

Abbreviation

TNFSF4; OX40L

Synonyms

OX-40L; TNFSF4; Tumor necrosis factor ligand 2B

UniProt

F7FL80

Accession Number

F7FL80

Expression System

HEK293 Cells

Tag

N-His

Sequence

Gln51-Leu183

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

16.5 kDa

Observed Molecular Weight

23-30 kDa

Species

Cynomolgus macaques