Recombinant Cynomolgus CD38/ADP-ribosyl Cyclase 1 Protein (His Tag)

Specifications

Catalog number

PKSQ050048-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells.

Abbreviation

CD38; ADP-ribosyl Cyclase 1

Synonyms

ADP-ribosyl cyclase 1; CD38; T10; cyclic ADP-ribose hydrolase

UniProt

Q5VAN0

Accession Number

Q5VAN0

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu44-Ile301

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

30.9 kDa

Observed Molecular Weight

38-50 kDa

Species

Cynomolgus macaques