Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag)

Specifications

Catalog number

PKSQ050064-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.

Abbreviation

PCSK9; Proprotein Convertase 9

Synonyms

PC9; PCSK9; Proprotein Convertase 9; Proprotein Convertase Subtilisin/Kexin Type 9; Subtilisin/Kexin-Like Protease PC9

UniProt

A8T662

Accession Number

A8T662

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln31-Gln152&Ser153-Gln692

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

14&59 kDa

Observed Molecular Weight

16-21&55-77 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 0.1M Arg, 0.1M Glu, 20% glycerol, 0.01% tween20, 5% Trehalose, pH 6.0.

Species

Macaca nemestrina