Recombinant Rhesus macaque ICOS/AILIM/CD278 Protein (Fc Tag)

Specifications

Catalog number

PKSQ050074-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige.

Abbreviation

ICOS; AILIM; CD278

Synonyms

AILIM; CD278; CVID1; ICOS; Inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule

UniProt

H9Z062

Accession Number

H9Z062

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gly20-Lys140

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

40.8 kDa

Observed Molecular Weight

50-60 kDa

Species

Rhesus macaque