Recombinant Cavia porcellus CTLA-4/CD152 Protein (His Tag)

Specifications

Catalog number

PKSQ050093-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cytotoxic Tlymphocyte 4 (CTLA-4, CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

Abbreviation

CTLA-4; CD152

Synonyms

CD152; CTLA-4; CTLA4; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4

UniProt

H0VUB1

Accession Number

H0VUB1

Expression System

P.Pichia

Tag

C-His

Sequence

Ala37-Asp161

Applications

Cell culture

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

16-35 kDa

Observed Molecular Weight

18-40 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

Species

Cavia porcellus