Recombinant Rhesus Macaque TNF Receptor II/TNF RII/TNFRSF1B/CD120b (C-Fc)

Specifications

Catalog number

PKSQ050114-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B) is a member of the Tumor Necrosis Factor Receptor Superfamily. TNFRSF1B contains four TNFR-Cys repeats. TNFRSF1B can be cleaved into the following 2 chains: Tumor necrosis factor receptor superfamily member 1b and membrane form and Tumor necrosis factor-binding protein 2. TNFRSF1B is a receptor with high affinity for TNFSF2/TNF-α and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-α. TNFRSF1B mediates most of the metabolic effects of TNF-α. TNF-α-induced apoptosis suggests that it regulates TNF-α function by antagonizing its biological activity.

Abbreviation

TNFRSF1B; CD120b

Synonyms

TNF RII; TNF-RII; TNFRII; Tnfrsf1b; Tumor necrosis factor receptor superfamily member 1b

UniProt

F7EAF8

Accession Number

F7EAF8

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Leu23-Asp257

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

52.0 kDa

Observed Molecular Weight

60-80 kDa

Species

Rhesus Macaque