Recombinant Cynomolgus PVRIG (C-6His)

Specifications

Catalog number

PKSQ050123-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

Abbreviation

PVRIG

Synonyms

C7orf15; C7orf15MGC138295; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; transmembrane protein PVRIG

UniProt

A0A2K5WVV8

Accession Number

A0A2K5WVV8

Expression System

HEK293 Cells

Tag

C-His

Sequence

Thr41-Asp171

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.5 kDa

Observed Molecular Weight

20-30 kDa

Species

Cynomolgus macaques