Recombinant Rat EGFR/ErbB1 Protein (His Tag)

Specifications

Catalog number

PKSR030363

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α , betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT) . In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

Synonyms

EGFR

UniProt

E7CXR8

Accession Number

E7CXR8

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Ser646

Applications

ELISA

Endotoxin

Please contact us for more information.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

Measured by its ability to bind recombinant human EGF-Fc and mouse EGF-Fc in functional ELISA.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

70.7 kDa

Observed Molecular Weight

93-110 kDa

Species

Rat