Recombinant Rat HER2/ErbB2 Protein (Fc Tag)

Specifications

Catalog number

PKSR030373

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Synonyms

CD340; ENV; ENVW; ERBB2; ERVWE1; Epidermal growth factor receptor-related protein; HER-2; HER-2/neu; HER2; HERV-7q; HERV-W-ENV; HERV7Q; HERVW; HERVWENV; MLN 19; MLN19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Receptor tyrosine-protein kinase erbB-2; p185erbB2; p185neu

UniProt

P06494

Accession Number

AAH61863.1

Expression System

HEK293 Cells

Tag

C-hFc

Sequence

Met 4-Thr 656

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

97.0 kDa

Observed Molecular Weight

130 kDa

Species

Rat