Anti-Frizzled-6 FZD6 Antibody

About this product

Boster Bio Anti-Frizzled-6 FZD6 Antibody catalog # A04241-1. Tested in ELISA, IF, IHC-P, WB applications. This antibody reacts with Human.

Specifications

Catalog number

A04241-1

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Frizzled-6; Fz-6; hFz6; FZD6;

Gene Name

FZD6

UniProt

O60353

Host

Rabbit

Reactivity

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human FZD6. AA range:116-165

Clonality

Polyclonal

Tissue Specificity

Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.

Applications

ELISA, IF, IHC-P, WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity) .

Molecular Weight

79292 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Frizzled-6

Subcellular Location

Membrane

Protein Name

Frizzled-6