Anti-Serine-protein kinase ATM ATM Monoclonal Antibody

About this product

Boster Bio Anti-Serine-protein kinase ATM ATM Monoclonal Antibody catalog # M00014-2. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00014-2

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Synonyms

Serine-protein kinase ATM;2.7.11.1; Ataxia telangiectasia mutated; A-T mutated; ATM;

Gene Name

ATM

UniProt

Q13315

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant peptide derived from ATM

Clonality

Monoclonal

Clone

Clone: 1D1

Tissue Specificity

Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.

Applications

IHC

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Dilution

IHC 1:100-200

Form

Liquid

Function

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.

Molecular Weight

350687 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Serine-protein kinase ATM

Subcellular Location

Nucleus

Protein Name

Serine-protein kinase ATM