GMP Human GM-CSF Protein

Catalog number GMP-GMFH28-500ug

Discontinued

Price for GMP-GMFH28-500ug

Size / count 500 µg

This variant is discontinued and cannot be added to your cart.

About this product

GMP Human GM-CSF Protein (GMP-GMFH28) is expressed from human 293 cells (HEK293). It contains AA Ala 18 - Glu 144 (Accession # P04141).

Specifications

Catalog number: GMP-GMFH28-500ug
Size / count: 500 µg
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is also known as Colony stimulating factor 2 (granulocyte-macrophage), is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells, and is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exitthe circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer. Human GM-CSF glycosylated in its mature form. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients. The preliminary results have been promising. GM-CSF is also used as a medication to stimulate the production of white blood cells following chemotherapy.
Specifications: This protein carries no "tag". The protein has a calculated MW of 14.5 kDa. The protein migrates as 25 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Expression Region: Ala 18 - Glu 144
Host: HEK 293
Target: GM-CSF
Conjugation: Unconjugated
Tag: Native
Source: Human
Stability: -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution._x000D_ Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin: 10 EU/mg
Purity: 95%
Format: Powder-GMP
Buffer: PBS, pH7.4
Molecular Weight: 14.5 kDa
Shipping Conditions: Blue ice
Storage Conditions: -20°C

Frequently Asked Questions

What is the catalog number for GMP Human GM-CSF Protein?

The catalog number for GMP Human GM-CSF Protein is GMP-GMFH28-500ug.

Is GMP Human GM-CSF Protein in stock?

GMP Human GM-CSF Protein is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GMP Human GM-CSF Protein?

GMP Human GM-CSF Protein is manufactured by CRB.

What is the estimated delivery time for GMP Human GM-CSF Protein?

Estimated delivery time for GMP Human GM-CSF Protein is approximately 10 business day(s), depending on your location.

What is GMP Human GM-CSF Protein used for?

GMP Human GM-CSF Protein (GMP-GMFH28) is expressed from human 293 cells (HEK293). It contains AA Ala 18 - Glu 144 (Accession # P04141).

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.