GMP Human IL-15 Protein

Catalog number GMP-L15H13-500ug

Discontinued

Price for GMP-L15H13-500ug

Size / count 500 µg

This variant is discontinued and cannot be added to your cart.

About this product

GMP Human IL-15 (GMP-L15H13) is expressed from E.coli cells. It contains AA Asn 49 - Ser 162 (Accession # P40933-1).

Specifications

Catalog number: GMP-L15H13-500ug
Size / count: 500 µg
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
Specifications: This protein carries no "tag". The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa±3 kDa under reducing (R) condition (SDS-PAGE).
Expression Region: Asn 49 - Ser 162
Host: E. coli
Target: IL-15
Conjugation: Unconjugated
Tag: Native
Source: Human
Stability: -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution._x000D_ Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin: 10 EU/mg
Purity: 95%
Format: Powder-GMP
Buffer: 25 mM His, pH6.2
Molecular Weight: 12.8 kDa
Shipping Conditions: Blue ice
Storage Conditions: -20°C

Frequently Asked Questions

What is the catalog number for GMP Human IL-15 Protein?

The catalog number for GMP Human IL-15 Protein is GMP-L15H13-500ug.

Is GMP Human IL-15 Protein in stock?

GMP Human IL-15 Protein is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GMP Human IL-15 Protein?

GMP Human IL-15 Protein is manufactured by CRB.

What is the estimated delivery time for GMP Human IL-15 Protein?

Estimated delivery time for GMP Human IL-15 Protein is approximately 10 business day(s), depending on your location.

What is GMP Human IL-15 Protein used for?

GMP Human IL-15 (GMP-L15H13) is expressed from E.coli cells. It contains AA Asn 49 - Ser 162 (Accession # P40933-1).

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.