GMP Human IL-7 Protein

Catalog number GMP-L07H24-500ug

Discontinued

Price for GMP-L07H24-500ug

Size / count 500 µg

This variant is discontinued and cannot be added to your cart.

About this product

GMP Human IL-7 (GMP-L07H24) is expressed from human 293 cells (HEK293). It contains AA Asp 26 - His 177 (Accession # P13232-1).

Specifications

Catalog number: GMP-L07H24-500ug
Size / count: 500 µg
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: Interleukin 7 is also known as IL7, IL-7, and is a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by lymphocytes. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells, It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis. IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor. Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma). Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients. IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant.
Specifications: This protein carries no "tag". The protein has a calculated MW of 17.4 kDa. The protein migrates as 23 kDa and 28 kDa (±3 kDa) under reducing (R) condition (SDS-PAGE) due to glycosylation.
Expression Region: Asp 26 - His 177
Host: HEK 293
Target: IL-7
Conjugation: Unconjugated
Tag: Native
Source: Human
Stability: -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution._x000D_ Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin: 10 EU/mg
Purity: 95%
Format: Powder-GMP
Buffer: PBS, pH7.4
Molecular Weight: 17.4 kDa
Shipping Conditions: Blue ice
Storage Conditions: -20°C

Frequently Asked Questions

What is the catalog number for GMP Human IL-7 Protein?

The catalog number for GMP Human IL-7 Protein is GMP-L07H24-500ug.

Is GMP Human IL-7 Protein in stock?

GMP Human IL-7 Protein is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GMP Human IL-7 Protein?

GMP Human IL-7 Protein is manufactured by CRB.

What is the estimated delivery time for GMP Human IL-7 Protein?

Estimated delivery time for GMP Human IL-7 Protein is approximately 10 business day(s), depending on your location.

What is GMP Human IL-7 Protein used for?

GMP Human IL-7 (GMP-L07H24) is expressed from human 293 cells (HEK293). It contains AA Asp 26 - His 177 (Accession # P13232-1).

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.