GMP Human IL-21 Protein

Catalog number GMP-L21H25-500ug

Discontinued

Price for GMP-L21H25-500ug

Size / count 500 µg

This variant is discontinued and cannot be added to your cart.

About this product

GMP Human IL-21 Protein (GMP-L21H25) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 162 (Accession # Q9HBE4-1).

Specifications

Catalog number: GMP-L21H25-500ug
Size / count: 500 µg
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Specifications: This protein carries no "tag". The protein has a calculated MW of 15.5 kDa. The protein migrates as 16 kDa±3 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Expression Region: Gln 30 - Ser 162
Host: HEK 293
Target: IL-21
Conjugation: Unconjugated
Tag: Native
Source: Human
Stability: -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution._x000D_ Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin: 10 EU/mg
Purity: 95%
Format: Powder-GMP
Buffer: PBS, pH7.4
Molecular Weight: 15.5 kDa
Shipping Conditions: Blue ice
Storage Conditions: -20°C

Frequently Asked Questions

What is the catalog number for GMP Human IL-21 Protein?

The catalog number for GMP Human IL-21 Protein is GMP-L21H25-500ug.

Is GMP Human IL-21 Protein in stock?

GMP Human IL-21 Protein is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GMP Human IL-21 Protein?

GMP Human IL-21 Protein is manufactured by CRB.

What is the estimated delivery time for GMP Human IL-21 Protein?

Estimated delivery time for GMP Human IL-21 Protein is approximately 10 business day(s), depending on your location.

What is GMP Human IL-21 Protein used for?

GMP Human IL-21 Protein (GMP-L21H25) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 162 (Accession # Q9HBE4-1).

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.