SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)

Catalog number SPN-C522c-1mg

Discontinued

Price for SPN-C522c-1mg

Size / count 1 mg

This variant is discontinued and cannot be added to your cart.

About this product

SARS-CoV-2 Spike Trimer, His Tag (BA.3/Omicron) (SPN-C522c) is expressed from human 293 cells (HEK293). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.3; GISAID clade: GRA; Nextstrain clade: 21M). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.

Specifications

Catalog number: SPN-C522c-1mg
Size / count: 1 mg
Dry ice: Yes
Hazardous: No
Discontinued: Yes
Background: It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Specifications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 137.8 kDa. The protein migrates as 160-200 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Host: HEK 293
Target: Spike protein
Conjugation: Unconjugated
Tag: C-10×His
Source: SARS-CoV-2
Stability: The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin: 1.0 EU per μg
Purity: 95%
Bioactivity: Immobilized SARS-CoV-2 Spike Trimer, His Tag (BA.3/Omicron) (Cat. No. SPN-C522c) at 1 μg/mL (100 μL/well) can bind Human ACE2, Fc Tag (Cat. No. AC2-H5257) with a linear range of 2-31 ng/mL (QC tested).
Format: Liquid
Buffer: 0.1 M Sodium citrate, pH5.5
Molecular Weight: 137.8 kDa
Shipping Conditions: Dry ice
Storage Conditions: -70°C

Frequently Asked Questions

What is the catalog number for SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)?

The catalog number for SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) is SPN-C522c-1mg.

Is SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) in stock?

SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) is currently made to order / not held in immediate stock. Contact us for lead time.

Are there any special shipping requirements for SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)?

SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) is requires dry ice shipping.

Who manufactures SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)?

SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) is manufactured by CRB.

What is the estimated delivery time for SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)?

Estimated delivery time for SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) is approximately 10 business day(s), depending on your location.

What is SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified) used for?

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.