GMP Human IL-2 Protein

Catalog number GMP-L02H14-1×10^7IU

Discontinued

Price for GMP-L02H14-1×10^7IU

Size / count 1x 10^7 IU

This variant is discontinued and cannot be added to your cart.

About this product

GMP Human IL-2 Protein (GMP-L02H14) is expressed from E. coli cells. It contains AA Ala 21 - Thr 153 (Accession # P60568-1).

Specifications

Catalog number: GMP-L02H14-1×10^7IU
Size / count: 1x 10^7 IU
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.
Specifications: This protein carries no "tag". The protein has a calculated MW of 15.4 kDa. The protein migrates as 16 kDa±2 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
Expression Region: Ala 21 - Thr 153
Host: E. coli
Target: IL-2
Conjugation: Unconjugated
Tag: Native
Source: Human
Stability: -20°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution._x000D_Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin: 5.0 EU/ Vial
Purity: 95%
Format: Powder-GMP
Buffer: phosphate
Molecular Weight: 15.4 kDa
Shipping Conditions: Blue ice
Storage Conditions: -20°C, aviod light

Frequently Asked Questions

What is the catalog number for GMP Human IL-2 Protein?

The catalog number for GMP Human IL-2 Protein is GMP-L02H14-1×10^7IU.

Is GMP Human IL-2 Protein in stock?

GMP Human IL-2 Protein is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GMP Human IL-2 Protein?

GMP Human IL-2 Protein is manufactured by CRB.

What is the estimated delivery time for GMP Human IL-2 Protein?

Estimated delivery time for GMP Human IL-2 Protein is approximately 10 business day(s), depending on your location.

What is GMP Human IL-2 Protein used for?

GMP Human IL-2 Protein (GMP-L02H14) is expressed from E. coli cells. It contains AA Ala 21 - Thr 153 (Accession # P60568-1).

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.