AF/LE Purified Anti-Human CD197 Antibody[G043H7]

Specifications

Catalog number

E-AB-F11590

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.

Abbreviation

CD197

Gene ID

1236

UniProt

P32248

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human CD197 protein

Target

EBI; CDw; BLR; EVI; CMKBR; CC-CKR; CCR; CCR7; BLR2; CC-CKR-7; CCR-7; CD197; CDw197; CMKBR7; EBI1; EVI1; EBI-1; BLR-2; CMKBR7

Clonality

Monoclonal

Clone

G043H7

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Immunology; Signal Transduction

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Isotype

Mouse IgG2a, κ