Anti-DKK1 Antibody Picoband® (Biotine Conjugate)

Catalog number A00632-Biotin

Price for A00632-Biotin

Size / count 100 µg/Vial

About this product

Boster Bio Anti-DKK1 Antibody Picoband® catalog # A00632. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number: A00632-Biotin
Size / count: 100 µg/Vial
Dry ice: No
Hazardous: No
Discontinued: No
Background: DKK1, Dickkopf-related protein 1, is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. By genomic sequence analysis, determined that the DKK1 gene contains 4 exons. The DKK1 gene is mapped to 10q11.2 using FISH. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
Synonyms: Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK; DKK1; UNQ492/PRO1008
Gene Name: dickkopf 1 homolog (Xenopus laevis)
UniProt: O94907
Host: Rabbit
Reactivity: Human,Mouse,Rat
Cross Reactivity: No cross-reactivity with other proteins.
Immunogen: E. coli-derived human DKK1 recombinant protein (Position: T32-H266).
Clonality: Polyclonal
Tissue Specificity: Placenta.
Applications: WB
Purification: Immunogen affinity purified.
Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Form: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti- apoptotic activity (By similarity).
Storage Conditions: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.
Fragment: Rabbit IgG
Applications Notes: Western blot, 0.1-0.5μg/ml<br>
Subcellular Location: Secreted.

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