Anti-KCND1 Antibody Picoband® (Dylight488 Conjugate)

About this product

Boster Bio Anti-KCND1 Antibody Picoband® catalog # PB9256. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9256-Dylight488

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as Kv4.1, is a human gene. It is mapped to Xp11.23. KCND1 encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. The diverse functions of Voltage-gated potassium (Kv) channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. In addition to that, KCND1 is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.

Synonyms

Potassium voltage-gated channel subfamily D member 1;Voltage-gated potassium channel subunit Kv4.1;KCND1;

Gene Name

Potassium voltage-gated channel subfamily D member 1

UniProt

Q9NSA2

Host

Rabbit

Reactivity

Human,Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human KCND1 recombinant protein (Position: T442-L647). Human KCND1 shares 90% amino acid (aa) sequence identity with mouse KCND1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain. .

Applications

WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I (To) current in heart and I (Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.1-0.5μg/ml, Human, Mouse<br>

Subcellular Location

Membrane; Multi-pass membrane protein. Cell projection, dendrite .

Sequence Similarities

Belongs to the integrin alpha chain family.

Protein Name

Potassium voltage-gated channel subfamily D member 1