Anti-Osteocalcin/BGLAP Antibody (Dylight488 Conjugate)

About this product

Boster Bio Anti-Osteocalcin/BGLAP Antibody Picoband® catalog # PB9920. Tested in Flow Cytometry, IHC applications. This antibody reacts with Rat.

Specifications

Catalog number

PB9920-Dylight488

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein found in bone and dentin. In humans, the osteocalcin is encoded by the BGLAP gene. Its receptor is GPRC6A. It is mapped to 1q22. Osteocalcin may play a role in the body's metabolic regulation and is pro-osteoblastic, or bone-building. It acts as a hormone in the body, causing beta cellsin the pancreas to release more insulin, and at the same time ing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. Also, it may play a role in male fertility. And it is found that picomolar amounts of osteocalcin affected insulin secretion and beta-cell proliferation.

Synonyms

Osteocalcin;Bone Gla protein;BGP;Gamma-carboxyglutamic acid-containing protein;Bglap;Bglap2;

Gene Name

Osteocalcin

UniProt

P04640

Host

Rabbit

Reactivity

Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived rat Osteocalcin recombinant protein (Position: Y50-V99). Rat Osteocalcin shares 80.9% and 68.9% amino acid (aa) sequence identity with human and mouse Osteocalcin, respectively.

Clonality

Polyclonal

Tissue Specificity

Bone.

Applications

Flow Cytometry,IHC

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Rat, By Heat<br> Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Rat

Subcellular Location

Secreted.

Protein Name

Osteocalcin