- Catalog number
- A18460-1-Dylight594
- Size / count
- 100 µg
- Dry ice
- No
- Hazardous
- No
- Discontinued
- Yes
- Background
- Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson’s disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The LRRC73 gene product has been provisionally designated LRRC73 pending further characterization.
- Synonyms
- 70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
- Gene Name
- Serine/threonine-protein kinase AtPK1/AtPK6
- Gene ID
- 221424
- UniProt
- Q5JTD7
- Host
- Rabbit
- Reactivity
- Human
- Cross Reactivity
- No cross reactivity with other proteins.
- Immunogen
- E.coli-derived human LRRC73 recombinant protein (Position: M1-Q249).
- Clonality
- Polyclonal
- Tissue Specificity
- Expressed in all tissues.
- Applications
- WB,ICC,IF,Flow Cytometry,ELISA
- Purification
- Immunogen affinity purified.
- Concentration
- Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
- Form
- Lyophilized
- Reconstitution
- Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
- Function
- Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.
- Components
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
- References & Citations
- 1. Sakai, Y. , Shaw, C. A. , Dawson, B. C. , Dugas, D. V. , Al-Mohtaseb, Z. , & Hill, D. E. , et al. (2011). Protein interactome reveals converging molecular pathways among autism disorders. Science Translational Medicine, 3(86), 86ra49.
2. The dna sequence and analysis of human chromosome 6. Nature.
3. Capalbo, L. , Bassi, Z. I. , Geymonat, M. , Todesca, S. , Copoiu, L. , & Enright, A. J. , et al. The midbody interactome reveals unexpected roles for pp1 phosphatases in cytokinesis. Nature Communications.
- Storage Conditions
- At -20℃ for one year from date of receipt.
After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months.
Avoid repeated freezing and thawing.
- Calculated Molecular Weight
- 52588 MW
- Observed Molecular Weight
- 42 kDa
- Fragment
- IgG
- Applications Notes
- Western blot, 0.25-0.5 μg/ml, Human<br>
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human<br>
Flow Cytometry (Fixed), 1-3 μg/1x10<sup>6</sup> cells, Human<br>
ELISA, 0.1-0.5 μg/ml, -<br>
- Subcellular Location
- Cytoplasm. Nucleus.
- Protein Name
- Serine/threonine-protein kinase AtPK1/AtPK6
