Anti-Vasopressin V1a receptor AVPR1A Antibody Picoband®, Dylight594 Conjugate

About this product

Boster Bio Anti-Vasopressin V1a receptor AVPR1A Antibody catalog # PA2248. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2248-Dylight594

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major receptor types for arginine vasopressin  (AVPR1B and AVPR2 being the others). It belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. This gene is mapped to 12q14.2. AVPR1A is present throughout the brain, as well as in the periphery, in the liver, kidney, and vasculature. The protein encoded by this gene acts as receptor for arginine vasopressin. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis.

Synonyms

Vasopressin V1a receptor;V1aR;AVPR V1a;Antidiuretic hormone receptor 1a;Vascular/hepatic-type arginine vasopressin receptor;Avpr1a;

Gene Name

Vasopressin V1a receptor

UniProt

P30560

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of rat AVPR1A, different from the related human and mouse sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Localized within gonadotropes of the anterior pituitary of the brain. Broadly distributed throughout the cerebral cortex. .

Applications

WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Involved in social memory formation. .

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References & Citations

1. Birnbaumer, M. Vasopressin receptors. Trends Endocr. Metab. 11: 406-410, 2000. 2. Caldwell HK, Lee HJ, Macbeth AH, Young WS (2008). "Vasopressin: behavioral roles of an ‘original’ neuropeptide". Prog Neurobiol 84 (1): 1–24.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

47655 MW

Observed Molecular Weight

47 kDa

Fragment

Rabbit IgG

Specificity

No cross reactivity with other proteins.

Applications Notes

Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse<br>

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Located in cytoplasmic vesicles dispersed throughout the cell cytoplasm and to the plasma membrane.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Protein Name

Vasopressin V1a receptor