Anti-Cortisol Binding Globulin/SERPINA6 Antibody Picoband®, PE Conjugate

About this product

Boster Bio Anti-Cortisol Binding Globulin/SERPINA6 Antibody catalog # PA2230. Tested in IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2230-PE

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Corticosteroid-binding globulin (CBG), also known as Serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is mapped 14q32.13. This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.

Synonyms

Corticosteroid-binding globulin;CBG;Serpin A6;Transcortin;SERPINA6;CBG;

Gene Name

Corticosteroid-binding globulin

UniProt

P08185

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Cortisol Binding Globulin.

Clonality

Polyclonal

Tissue Specificity

Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.

Applications

IHC,ICC,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. .

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References & Citations

1. Buss, C., Schuelter, U., Hesse, J., Moser, D., Phillips, D. I., Hellhammer, D., Meyer, J. Haploinsufficiency of the SEPRINA6 gene is associated with severe muscle fatigue: a de novo mutation in corticosteroid-binding globulin deficiency. J. Neural Transm. 114: 563-569, 2007. 2. Torpy, D. J., Bachmann, A. W., Grice, J. E., Fitzgerald, S. P., Phillips, P. J., Whitworth, J. A., Jackson, R. V. Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension. J. Clin. Endocr. Metab. 86: 3692-3700, 2001.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

45141 MW

Observed Molecular Weight

60 kDa

Fragment

Rabbit IgG

Specificity

No cross reactivity with other proteins.

Applications Notes

Immunocytochemistry , 0.5-1μg/ml, Human<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat<br>Western blot, 0.1-0.5μg/ml, Human<br>

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the serpin family.

Protein Name

Corticosteroid-binding globulin