Anti-Cathepsin D/Ctsd Antibody Picoband® (APC Conjugate)

About this product

Boster Bio <a href="https://www.bosterbio.com/services/assay-services/elisa-testing-service" style="color:#EA8D28">Anti-Cathepsin D</a>/Ctsd Antibody Picoband&reg; catalog # A01361. Tested in ELISA, IF, ICC, and WB applications. This antibody reacts with Mouse and Rat, offering an essential tool for scientific applications such as cell lysate analysis and breast adenocarcinoma cell line research. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01361-APC

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in signal peptide and a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation of proteins, cell invasion, and apoptosis, playing a significant role in cell signaling technology. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer's disease and it has been considered as a breast cancer tumor marker.

Synonyms

Cathepsin D; Ctsd

Gene Name

cathepsin D

UniProt

P18242

Host

Rabbit

Reactivity

Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse Cathepsin D recombinant protein (Position: K161-Q358).

Clonality

Polyclonal

Applications

ELISA,IF,ICC,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Applications Notes

Western blot,0.1-0.5μg/ml<br> Immunocytochemistry/Immunofluorescence, 5 μg/ml<br> ELISA,0.1-0.5μg/ml<br>

Subcellular Location

Lysosome. Melanosome. Secreted, extracellular space.