Anti-Cytochrome P450 2U1 CYP2U1 Antibody Picoband®, APC Conjugate

About this product

Boster Bio Anti-Cytochrome P450 2U1 CYP2U1 Antibody catalog # PA2022. Tested in IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2022-APC

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CYP2U1 (Cytochrome P450, Family 2, Subfamily U, Polypeptide 1), is a protein that in humans is encoded by the CYP2U1 gene. Members of the P450 enzyme family have roles in the tissue-specific conversion of substrates into locally active hormones, <a href="https://www.bosterbio.com/blog/post/detecting-vitamins-in-laboratories" style="color:#EA8D28">vitamins</a>, and signaling molecules, including arachidonic acid derivatives known as eicosanoids. The International Radiation Hybrid Mapping Consortium mapped the CYP2U1 gene to chromosome 4.Chuang et al. (2004) stated that CYP2U1 maps to 4q25. Using recombination experiments in Sf9 insect cells, Chuang et al. (2004) found that CYP2U1 metabolized arachidonic acid, docosahexaenoic acid (DHA), and other long chain fatty acids. Chuang et al. (2004) suggested that CYP2U1 may play a role in brain and immune functions.

Synonyms

Cytochrome P450 2U1;1.14.14.1;CYP2U1;

Gene Name

Cytochrome P450 2U1

UniProt

Q7Z449

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human CYP2U1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed with stronger expression in thymus, heart and cerebellum. .

Applications

IHC,ICC,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. .

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References & Citations

1. Chuang, S. S., Helvig, C., Taimi, M., Ramshaw, H. A., Collop, A. H., Amad, M., White, J. A., Petkovich, M., Jones, G., Korczak, B. CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. J. Biol. Chem. 279: 6305-6314, 2004. 2. Tesson, C., Nawara, M., Salih, M. A. M., Rossignol, R., Zaki, M. S., Al Balwi, M., Schule, R., Mignot, C., Obre, E., Bouhouche, A., Santorelli, F. M., Durand, C. M., and 30 others. Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia. Am. J. Hum. Genet. 91: 1051-1064, 2012.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

61987 MW

Observed Molecular Weight

22 kDa

Fragment

Rabbit IgG

Specificity

No cross reactivity with other proteins.

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat <br>Immunocytochemistry , 0.5-1μg/ml, Human, -<br>Western blot, 0.1-0.5μg/ml, Human<br>

Subcellular Location

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane .

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Protein Name

Cytochrome P450 2U1