Anti-RTKN2 Antibody Picoband®, iFluor647 Conjugate

About this product

Boster Bio Anti-RTKN2 Antibody Picoband® catalog # A12576-1. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A12576-1-iFluor647

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Rhotekin 2 is a protein in humans that is encoded by the RTKN2 gene. The RTKN2 gene encodes a protein known as Rhotekin-2, which is involved in various cellular processes, including cytoskeletal organization, cell migration, and signal transduction. RTKN2 interacts with Rho GTPases, particularly RhoA, and modulates their activity to regulate actin cytoskeleton dynamics and cell morphology. This protein plays a role in cell adhesion and migration, with implications for tissue development, wound healing, and cancer metastasis. Additionally, RTKN2 has been linked to synaptic plasticity and neuronal development in the brain. Dysregulation of RTKN2 expression or function has been associated with neurological disorders, cardiovascular diseases, and cancer progression. Elucidating the molecular mechanisms underlying RTKN2's diverse functions is crucial for understanding its physiological roles and its potential as a therapeutic target for various diseases.

Gene Name

RTKN2

Gene ID

219790

UniProt

Q8IZC4

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

E.coli-derived human RTKN2 recombinant protein (Position: M1-D572). Human RTKN2 shares 71.8% amino acid (aa) sequence identity with mouse RTKN2.

Clonality

Polyclonal

Applications

ELISA,Flow Cytometry,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Collier, F. M., Gregorio-King, C. C., Gough, T. J., Talbot, C. D., Walder, K., Kirkland, M. A. Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2. Biochem. Biophys. Res. Commun. 324: 1360-1369, 2004. 2. Collier, F. M., Loving, A., Baker, A. J., McLeod, J., Walder, K., Kirkland, M. A. RTKN2 induces NF-kappaB dependent resistance to intrinsic apoptosis in HEK cells and regulates BCL-2 genes in human CD4+ lymphocytes. J. Cell Death 2: 9-23, 2009. Note: Electronic Article. 3. Gregorio-King, C. C., Gough, T., Van Der Meer, G. J., Hosking, J. B., Waugh, C. M., McLeod, J. L., Collier, F. M., Kirkland, M. A. Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. J. Steroid Biochem. Molec. Biol. 88: 311-320, 2004.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

69 kDa

Observed Molecular Weight

69 kDa

Applications Notes

Western blot, 0.1-0.25 μg/ml, Human, Mouse, Rat<br>. Flow Cytometry (Fixed), 1-3 μg /1x10⁶ cells, Human<br> ELISA, 0.1-0.5 μg/ml, -<br>