Anti-Cathepsin D Ctsd Monoclonal Antibody, Carrier-free

About this product

Boster Bio Anti-Cathepsin D Ctsd Monoclonal Antibody catalog # MA1013. Tested in IHC, WB applications. This antibody reacts with Human.

Specifications

Catalog number

MA1013-carrier-free

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Cathepsin D is mapped to chromosome 11. The amino acid sequence predicted from the cDNA sequence shows that human cathepsin D consists of 412 amino acids with 20 and 44 amino acids in a pre- and a prosegment, respectively.

Synonyms

Cathepsin D;3.4.23.5;Cathepsin D 12 kDa light chain;Cathepsin D 9 kDa light chain;Cathepsin D 34 kDa heavy chain;Cathepsin D 30 kDa heavy chain;Ctsd;

Gene Name

Cathepsin D

Gene ID

Human(1509), Mouse(13033), Rat(171293)

UniProt

P24268

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Human liver cathepsin D.

Clonality

Monoclonal

Clone

Clone: CTD-19

Tissue Specificity

CTSD: Expressed in the aorta extrcellular space (atprotein level).

Applications

IHC,WB

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Acid protease active in intracellular protein breakdown.

Components

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

References & Citations

1. Hasilik, A.; von Figura, K.; Grzeschik, K.-H. : Assignment of a gene for human cathepsin D to chromosome 11. (Abstract) Cytogenet. Cell Genet. 32: 284 only, 1982. 2. Qin, S.; Nakai, H.; Byers, M. G.; Eddy, R. L.; Haley, L. L.; Henry, W. M.; Wang, X.; Watkins, P. C.; Chirgwin, J. M.; Shows, T. B. : Mapping FSHB, CAT, and CTSD to specific sites on 11p. (Abstract) Cytogenet. Cell Genet. 46: 678 only, 1987. 3. Faust, P. L.; Kornfeld, S.; Chirgwin, J. M. : Cloning and sequence analysis of cDNA for human cathepsin D. Proc. Nat. Acad. Sci. 82: 4910-4914, 1985.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

44681 MW

Observed Molecular Weight

28 kDa

Fragment

Mouse IgG2a

Specificity

No cross reactivity with other proteins.

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 1-2μg/ml, Human, By Heat <br>Western blot, 0.5-1μg/ml, Human<br>

Subcellular Location

Lysosome. Melanosome . Secreted, extracellular space .

Sequence Similarities

Belongs to the peptidase A1 family.

Protein Name

Cathepsin D