Anti-Tyrosine Hydroxylase Antibody (Monoclonal, TH-16), Carrier-free

About this product

Boster Bio Anti-Tyrosine Hydroxylase Antibody (Monoclonal, TH-16) catalog # MA1100. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rabbit, Rat.

Specifications

Catalog number

MA1100-carrier-free

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Human TH gene contains 13 primary exons and spans approximately 8 kb. TH is in the 11p15.5 region.

Synonyms

Tyrosine 3-monooxygenase;1.14.16.2;Tyrosine 3-hydroxylase;TH;Th;

Gene Name

Tyrosine 3-monooxygenase

Gene ID

Human(7054), Mouse(21823), Rat(25085)

UniProt

P04177

Host

Mouse

Reactivity

Human,Mouse,Rabbit,Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Rat tyrosine hydroxylase (TH).

Clonality

Monoclonal

Clone

Clone: TH-16

Tissue Specificity

TH: Mainly expressed in the brain and adrenalglands.

Applications

IHC,WB

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Plays an important role in the physiology of adrenergic neurons.

Components

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

References & Citations

1. Brilliant, M. H.; Niemann, M. M.; Eicher, E. M. : urine tyrosine hydroxylase maps to the distal end of chromosome 7 within a region conserved in mouse and man. J. Neurogenet. 4: 259-266, 1987. 2. Craig, S. P.; Buckle, V. J.; Craig, I. W.; Lamouroux, A.; Mallet, J. : Localization of the human tyrosine hydroxylase gene to chromosome 11p15. (Abstract) Cytogenet. Cell Genet. 40: 610 only, 1985. 3. Craig, S. P.; Buckle, V. J.; Lamouroux, A.; Mallet, J.; Craig, I. : Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways. Cytogenet. Cell Genet. 42: 29-32, 1986.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

55966 MW

Observed Molecular Weight

59 kDa

Fragment

Mouse IgG1

Specificity

No cross reactivity with other proteins.

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, rat, rabbit, By Heat <br>Immunohistochemistry (Frozen Section), 0.5-1μg/ml, Human, rat, rabbit, -<br>Western blot, 0.25-0.5μg/ml, Human, mouse, rat, rabbit<br>

Subcellular Location

Cytoplasm, cytoskeleton.

Sequence Similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Protein Name

Tyrosine 3-monooxygenase