Anti-IAP2 BIRC3 Rabbit Monoclonal Antibody, Carrier-free

About this product

Boster Bio Anti-IAP2 BIRC3 Rabbit Monoclonal Antibody catalog # M01562. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human.

Specifications

Catalog number

M01562-carrier-free

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Synonyms

Baculoviral IAP repeat-containing protein 3;6.3.2.-;Apoptosis inhibitor 2;API2;C-IAP2;IAP homolog C;Inhibitor of apoptosis protein 1;IAP-1;hIAP-1;hIAP1;RING finger protein 49;TNFR2-TRAF-signaling complex protein 1;BIRC3;API2, IAP1, MIHC, RNF49;

Gene Name

Baculoviral IAP repeat-containing protein 3

UniProt

Q13489

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human IAP2

Clonality

Monoclonal

Clone

Clone: BOB-2

Tissue Specificity

Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.

Applications

WB,IHC,ICC,IF,IP

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite ions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

68372 MW

Observed Molecular Weight

69 kDa

Fragment

Rabbit IgG

Applications Notes

WB 1:1000-1:2000<br>IHC 1:50-1:100<br>ICC/IF 1:50-1:100<br>IP 1:50

Subcellular Location

Cytoplasm . Nucleus .

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)