Anti-SETD7/Set7 Rabbit Monoclonal Antibody, Carrier-free

About this product

Boster Bio Anti-SETD7/Set7 Rabbit Monoclonal Antibody catalog # M02793. Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M02793-carrier-free

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Synonyms

Histone-lysine N-methyltransferase SETD7;2.1.1.43;Histone H3-K4 methyltransferase SETD7;H3-K4-HMTase SETD7;Lysine N-methyltransferase 7;SET domain-containing protein 7;SET7/9;SETD7;KIAA1717, KMT7, SET7, SET9;

Gene Name

Histone-lysine N-methyltransferase SETD7

UniProt

Q8WTS6

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human SETD7

Clonality

Monoclonal

Clone

Clone: ABA-19

Tissue Specificity

Widely expressed. Expressed in pancreatic islets.

Applications

WB,IP

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

40721 MW

Observed Molecular Weight

48 kDa

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000<br>IP 1:50

Subcellular Location

Nucleus. Chromosome .

Protein Name

T-cell surface glycoprotein CD3 zeta chain