Anti-UCHL3 Rabbit Monoclonal Antibody, Carrier-free

About this product

Boster Bio Anti-UCHL3 Rabbit Monoclonal Antibody catalog # M05004. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M05004-carrier-free

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Synonyms

Ubiquitin carboxyl-terminal hydrolase isozyme L3;UCH-L3;3.4.19.12;Ubiquitin thioesterase L3;UCHL3;

Gene Name

Ubiquitin carboxyl-terminal hydrolase isozyme L3

UniProt

P15374

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human UCHL3

Clonality

Monoclonal

Clone

Clone: BGE-21

Tissue Specificity

Highly expressed in heart, skeletal muscle, and testis. .

Applications

WB

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Inly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB (+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

26183 MW

Observed Molecular Weight

35 kDa

Fragment

Rabbit IgG

Applications Notes

WB 1:1000-1:2000

Subcellular Location

Cytoplasm.

Protein Name

T-cell surface glycoprotein CD3 zeta chain