Anti-Follistatin Rabbit Monoclonal Antibody, Carrier-free

About this product

Boster Bio Anti-Follistatin Rabbit Monoclonal Antibody catalog # M00972. Tested in WB application. This antibody reacts with Human, Rat.

Specifications

Catalog number

M00972-carrier-free

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Synonyms

Histone deacetylase 4;HD4;3.5.1.98;HDAC4;KIAA0288;

Gene Name

Histone deacetylase 4

UniProt

P19883

Host

Rabbit

Reactivity

Human,Rat

Immunogen

A synthesized peptide derived from human Follistatin

Clonality

Monoclonal

Clone

Clone: 17F79

Tissue Specificity

Ubiquitous.

Applications

WB

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

119040 MW

Observed Molecular Weight

180-230 kDa

Fragment

IgG

Applications Notes

WB 1:500-1:2000

Subcellular Location

Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)