Anti-Mast Cell Chymase Rabbit Monoclonal Antibody, Carrier-free

About this product

Boster Bio Anti-Mast Cell Chymase Rabbit Monoclonal Antibody catalog # M03446-1. Tested in WB, IHC applications. This antibody reacts with Human.

Specifications

Catalog number

M03446-1-carrier-free

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Synonyms

Advanced glycosylation end product-specific receptor;Receptor for advanced glycosylation end products;AGER;RAGE;

Gene Name

Advanced glycosylation end product-specific receptor

UniProt

P23946

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Mast Cell Chymase

Clonality

Monoclonal

Clone

Clone: 18C83

Tissue Specificity

Endothelial cells.

Applications

WB,IHC

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

42803 MW

Observed Molecular Weight

106 kDa

Fragment

IgG

Applications Notes

WB 1:1000-1:5000<br>IHC 1:50-1:200

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Protein Name

T-cell surface glycoprotein CD3 zeta chain