P85a Phosphoinositide 3-kinase a, regulatory subunit Bovine Recombinant Protein

Catalog number PROTP23727-01

Discontinued

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Price for PROTP23727-01

Size / count 2 µg

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About this product

Phosphoinositide 3-kinase subunit p85a Bovine Recombinant has a molecular weight of 83.5 kDa.

Specifications

Catalog number: PROTP23727-01
Size / count: 2 µg
Dry ice: No
Hazardous: No
Discontinued: Yes
Synonyms: Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase p85 subunit alpha; PtdIns-3-kinase p85-alpha; PI3K; P85a
Gene Name: PIK3R1
UniProt: P23727
Reactivity: Bovine
Source: Leishmania tarentolae
Purification: Greater than 90.0% as determined by SDS-PAGE.
Form: Sterile filtered liquid formualtion.
Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity) .
Shipping Conditions: Available
Storage Conditions: Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.
Other Gene Names: Phosphatidylinositol 3-kinase regulatory subunit alpha

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