Anti-TLR2 Antibody

Catalog number M00131-1-01

Discontinued

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About this product

Boster Bio Anti-TLR2 Antibody (Catalog # M00131-1) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number: M00131-1-01
Size / count: 50 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Synonyms: Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, CD282, TLR2, TIL4
Gene Name: TLR2
UniProt: O60603
Host: Mouse
Reactivity: Human
Immunogen: This TLR2 Antibody is generated from a mouse immunized with a recombinant protein .
Clonality: Monoclonal
Clone: Clone: 1070CT4.2.3.2
Tissue Specificity: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues
Applications: WB
Field of Research: Cardiovascular, Immunology, Microbiology, Signal Transduction, Inflammation, Innate Immunity, TLR Signaling
Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution: WB: 1:500-1:1000
Function: 21078852178896511042699510426996114411071662220516622205193627121580930316880211
Molecular Weight: 89838 Da
Shipping Conditions: Available
Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment: IgG1, κ
Subcellular Location: Membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single- pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.

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