Anti-VHL Antibody (C-term)

Catalog number A00079-2-01

Discontinued

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About this product

Boster Bio Anti-VHL Antibody (C-term) (Catalog # A00079-2) . Tested in IHC-P, Flow Cytometry, WB application (s) . This antibody reacts with Human.

Specifications

Catalog number: A00079-2-01
Size / count: 80 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein.
Synonyms: Von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL
Gene Name: VHL
UniProt: P40337
Host: Rabbit
Reactivity: Human
Immunogen: This VHL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-210 amino acids from the C-terminal region of human VHL.
Clonality: Polyclonal
Tissue Specificity: Expressed in the adult and fetal brain and kidney.
Applications: IHC-P, Flow Cytometry, WB
Field of Research: Cancer, Cell Biology, Metabolism
Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function: 109441131798112419584355109441131798112410944113179811241958435534290272
Molecular Weight: 24153 Da
Shipping Conditions: Available
Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment: Rabbit IgG
Subcellular Location: [Isoform 1]: Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated (PubMed:9751722) Colocalizes with ADRB2 at the cell membrane (PubMed:19584355)

Frequently Asked Questions

What is the catalog number for Anti-VHL Antibody (C-term)?

The catalog number for Anti-VHL Antibody (C-term) is A00079-2.

Is Anti-VHL Antibody (C-term) in stock?

Anti-VHL Antibody (C-term) is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-VHL Antibody (C-term)?

The safety data sheet for Anti-VHL Antibody (C-term) is available here: https://www.bosterbio.com/msds?sku=A00079-2.

What is Anti-VHL Antibody (C-term) used for?

Boster Bio Anti-VHL Antibody (C-term) (Catalog # A00079-2) . Tested in IHC-P, Flow Cytometry, WB application (s) . This antibody reacts with Human.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.