Anti-CHEK2 Antibody (N-term) — image 1 of 5

Product details

Anti-CHEK2 Antibody (N-term)

Catalog number A00277-1-01

Discontinued

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Size / count 80 µL

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About this product

Boster Bio Anti-CHEK2 Antibody (N-term) (Catalog # A00277-1) . Tested in WB, IF, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human.

Specifications

Catalog number: A00277-1-01
Size / count: 80 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53.
Synonyms: Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, Cds1 homolog, Hucds1, hCds1, Checkpoint kinase 2, CHEK2, CDS1, CHK2, RAD53
Gene Name: CHEK2
UniProt: O96017
Host: Rabbit
Reactivity: Human
Immunogen: This CHEK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-141 amino acids from the N-terminal region of human CHEK2.
Clonality: Polyclonal
Tissue Specificity: High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues
Applications: WB, IF, Flow Cytometry, IHC-P
Field of Research: Cancer
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Function: 25361978
Molecular Weight: 60915 Da
Shipping Conditions: Available
Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment: Rabbit IgG
Subcellular Location: [Isoform 2]: Nucleus. Note=Isoform 10 is present throughout the cell [Isoform 7]: Nucleus. [Isoform 12]: Nucleus.

Frequently Asked Questions

What is the catalog number for Anti-CHEK2 Antibody (N-term)?

The catalog number for Anti-CHEK2 Antibody (N-term) is A00277-1.

Is Anti-CHEK2 Antibody (N-term) in stock?

Anti-CHEK2 Antibody (N-term) is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-CHEK2 Antibody (N-term)?

The safety data sheet for Anti-CHEK2 Antibody (N-term) is available here: https://www.bosterbio.com/msds?sku=A00277-1.

What is Anti-CHEK2 Antibody (N-term) used for?

Boster Bio Anti-CHEK2 Antibody (N-term) (Catalog # A00277-1) . Tested in WB, IF, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.