Anti-Activin Receptor Type IA (ACVR1) Antibody (N-term)

About this product

Boster Bio Anti-Activin Receptor Type IA (ACVR1) Antibody (N-term) (Catalog # A00798-3) . Tested in WB, IHC-P application (s) . This antibody reacts with Human, Rat.

Specifications

Catalog number

A00798-3-01

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is an activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.

Synonyms

Activin receptor type-1, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2

Gene Name

ACVR1

UniProt

Q04771

Host

Rabbit

Reactivity

Human, Rat

Immunogen

This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human Activin Receptor Type IA (ACVR1) .

Clonality

Polyclonal

Tissue Specificity

Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells

Applications

WB, IHC-P

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

20628059229772371791140125354296974822817911401

Molecular Weight

57153 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

Rabbit IgG

Subcellular Location

Membrane; Single-pass type I membrane protein.

Prediction Reactivity

Bovine