Anti-CP Antibody (N-term)

About this product

Boster Bio Anti-CP Antibody (N-term) (Catalog # A02883) . Tested in WB, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number

A02883-01

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

CP is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe (II) transferrin to Fe (III) transferrin. Mutations in this protein cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities.

Synonyms

Ceruloplasmin, Ferroxidase, CP

Gene Name

CP

UniProt

P00450

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This CP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-151 amino acids from the N-terminal region of human CP.

Clonality

Polyclonal

Tissue Specificity

Expressed by the liver and secreted in plasma.

Applications

WB, Flow Cytometry, IHC-P

Field of Research

Cardiovascular, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe (2+) to Fe (3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu (2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity) .

Molecular Weight

122205 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

Rabbit IgG

Subcellular Location

Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments.